Clinical categories and prognostic factors of pediatric ventricular tachycardia

Clinical categories and prognostic factors of pediatric ventricular tachycardia

Clinical categories and prognostic factors of pediatric ventricular tachycardia

(구연):
Release Date : 2009. 10. 24(토)
Mi Kyoung Song, M.D., Eun Jung Bae, M.D., Jae Sook Baek, M.D., Sang Yun Lee, M.D., Gi Beom Kim, M.D., Chung Il Noh, M.D., Jung Yun Choi M.D.
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
송미경, 배은정, 백재숙, 이상윤, 김기범, 노정일, 최정연
서울대학교 소아과학 교실

Abstract

Purpose : Pediatric ventricular tachycardia (VT) has heterogeneous etiology and may have different clinical features. However there have been no data on the prevalence and clinical characteristics of pediatric VT in Korea. The aim of this study was to elucidate the clinical and electrophysiological features and prognostic factors of pediatric VT. Methods : We reviewed the medical records of 82 pediatric VT patients who visited our hospital from January 1999 to March 2009. We included the patients with ECG-documented VT and categorized them into 6 groups; idiopathic VT(n=39), catecholaminergic polymorphic VT(CPVT)(n=10), VT associated surgery of congenital heart disease(CHD) (n=14), VT associated myocarditis(n=8), VT associated cardiomyopathy(n=4), and miscellaneous(n=7). Median period of follow-up was 6.2years(range:0.7~23.3yrs). Results : Male and female ratio was 50:32. Sustained VT and nonsustained VT ratio was 53:28. 22.0% of them had polymorphic type. The age of onset was 9.4yrs (0.1~19.1yrs). Regarding the initial symptoms, 25.6% was asymptomatic, 29.3% showed syncope or seizure, 29.3% had palpitation, and 14.6% had cardiac arrest. Idiopathic VT(47.6%) and VT after CHD repair(17.1%) were common. Idiopathic sustained VT, LV origin(n=24) and RV origin(n=15), were successfully treated by radiofrequency catheter ablation(100% of success rate) and medically(72.2% of success rate , 13/18). Implantable cardioverter defibrillators were applied in 6 patients and most of them were in the groups of VT with CHD repair and VT with cardiomyopathy. The overall elimination rate of VT by treatment was 54.9%, partial response 20.7%, and spontaneous regression was 9.8%. The mortality rate was 7.3%. The incidence of life threatening event was higher especially in CPVT and VT with cardiomyopathy group(p0.05). CPVT group showed the worst prognosis and the 3-years event free survival rate was 10%. Event free survival rate were higher in the idiopathic VT and VT associated myocarditis with treatment (p0.05). The variables of significant correlation with death or cardiac arrest were clinical category, cardiomyopathy, polymorphic VT, and poorly controlled VT (p0.05). Conclusions : The clinical features and prognosises was different according to the VT categories. Tailored and definitive treatment to the pediatric VT may improve the outcome.

Keywords: ventricular tachycardia, ,